When doctors give heart drugs to patients, the time of day can make a big difference, according to new research by University of Guelph scientists. Many doctors prefer to give heart drugs to patients in the morning. But the study revealed that angiotensin-converting enzyme (ACE) inhibitors – commonly given to patients with high blood pressure or after a heart attack or during heart failure – improve heart structure and function when given at sleep time. In fact, when administered during wake time, ACE inhibitors are no more effective than a placebo, the study found. The research was conducted on mice with high blood pressure. Guelph professors Tami Martino, Department of Biomedical Sciences, Jeremy Simpson, Department of Human Health and Nutritional Sciences and Nazneen Tata conducted the study in the laboratory of Dr. Michael Sole at the Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre of Excellence in Toronto. The study will appear May 17 in the Journal of the American College of Cardiology
Showing posts with label ACE inhibitors. Show all posts
Showing posts with label ACE inhibitors. Show all posts
Monday, May 9, 2011
Heart medication best at bedtime, study reveals (Canada)
When doctors give heart drugs to patients, the time of day can make a big difference, according to new research by University of Guelph scientists. Many doctors prefer to give heart drugs to patients in the morning. But the study revealed that angiotensin-converting enzyme (ACE) inhibitors – commonly given to patients with high blood pressure or after a heart attack or during heart failure – improve heart structure and function when given at sleep time. In fact, when administered during wake time, ACE inhibitors are no more effective than a placebo, the study found. The research was conducted on mice with high blood pressure. Guelph professors Tami Martino, Department of Biomedical Sciences, Jeremy Simpson, Department of Human Health and Nutritional Sciences and Nazneen Tata conducted the study in the laboratory of Dr. Michael Sole at the Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre of Excellence in Toronto. The study will appear May 17 in the Journal of the American College of Cardiology
Sunday, January 18, 2009
Guideline alert for blood pressure patients as treatment combo fails
"Thousands of Canadians with high blood pressure (hypertension) are being treated with a drug combination that increases the risk of sudden cardiac death, kidney disease and the likelihood of dialysis, warns the Heart and Stroke Foundation. New guidelines from Canadian Hypertension Education Program (CHEP) based on international research funded in part by the Foundation will urge patients who have been prescribed a combination of ACE inhibitors and Angiotensin II Receptor Blockers (ARBs) to see their family physicians as soon as possible for a treatment change. 'These two popular categories of hypertension medication are each safe and effective treatments – but not together,' says Dr. Sheldon Tobe, spokesperson for the Heart and Stroke Foundation and CHEP executive member. As many as 175,000 Canadians with high blood pressure may be currently treated with this combination of medications." - Heart and Stroke Foundation
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