Advances transforming cardiac care (USA)

Have a heart problem? If it's fixable, there's a good chance it can be done without surgery, using tiny tools and devices that are pushed through tubes into blood vessels. Heart care is in the midst of a transformation. Many problems that once required sawing through the breastbone and opening up the chest for open heart surgery now can be treated with a nip, twist or patch through a tube. These minimal procedures used to be done just to unclog arteries and correct less common heart rhythm problems. Now some patients are getting such repairs for valves, irregular heartbeats, holes in the heart and other defects - without major surgery. Doctors even are testing ways to treat high blood pressure with some of these new approaches. All rely on catheters - hollow tubes that let doctors burn away and reshape heart tissue or correct defects through small holes into blood vessels. "This is the replacement for the surgeon's knife. Instead of opening the chest, we're able to put catheters in through the leg, sometimes through the arm," said Dr. Spencer King of St. Joseph's Heart and Vascular Institute in Atlanta

CARG Newsletter April 2013

The CARG Newsletter - April 2013 is now available online

Is your CARG membership up-to-date?

In the month of April 2013 CARG will be doing spot-checks to see if your membership is paid to date. Everyone is asked to please to make sure they are carrying their white membership cards with them at all times. Thanks in advance for your co-operation

Maintenance of equipment at the Field House

Gary Flegel has requested assistance in helping to maintain the equipment in the exercise room at the Field House. Work will entail cleaning and doing small repairs on the equipment. Please contact a Board Member or Gary if you are interested

Only one in 1,000 'heart healthy'

The American Heart Association recently issued a list of seven steps to follow to minimise the chances of suffering cardiovascular disease. Its "Life's Simple Seven" are: not smoking, being physically active, not being overweight, maintaining healthy cholesterol levels, keeping blood pressure down, regulating blood sugar levels, and eating healthily. But Professor Jean-Pierre Després, scientific director of the International Chair on Cardiometabolic Risk, said the number who met all seven criteria was vanishingly small. He said: "If you look at those simple seven, and you measure what percentage of different populations around the developed world meet those criteria, it's only 0.1 per cent. "In terms of having an optimal risk of cardiovascular disease, only one in 1,000 people is healthy." He continued: "If you only use the traditional risk factors like cholesterol and blood pressure you would probably end up with 15 per cent." But when one included exercise - or the lack of it - and diet, the number who were really healthy was far smaller. "Exercise and nutrition are the two hardest indicators of cardiovascular health to meet,"he said

Researchers create tomatoes that mimic actions of good cholesterol (USA)

UCLA researchers have genetically engineered tomatoes to produce a peptide that mimics the actions of good cholesterol when consumed. Published in the April issue of the Journal of Lipid Research their early study found that mice that were fed these tomatoes in freeze-dried, ground form had less inflammation and plaque build-up in their arteries. "This is one of the first examples of a peptide that acts like the main protein in good cholesterol and can be delivered by simply eating the plant," said senior author Dr. Alan M. Fogelman, executive chair of the department of medicine and director of the atherosclerosis research unit at the David Geffen School of Medicine at UCLA. "There was no need to isolate or purify the peptide - it was fully active after the plant was eaten." After the tomatoes were eaten, the peptide surprisingly was found to be active in the small intestine but not in the blood, suggesting that targeting the small intestine may be a new strategy to prevent diet-induced atherosclerosis, the plaque-based disease of the arteries that can lead to heart attacks and strokes

Sugary drinks linked to 180,000 annual deaths worldwide

Drinking non-diet sodas, sports drinks, fruit drinks, and other sugar-sweetened beverages could be associated with as many as 180,000 deaths worldwide each year, according to a new study led by researchers at the Harvard School of Public Health. The study, presented during the American Heart Association's Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions, utilized data collected as part of the 2010 Global Burden of Diseases Study to look at the global health impacts of sugar-sweetened beverages. According to that data, sodas and other sugary drinks could be linked to 133,000 diabetes deaths; 44,000 cardiovascular disease-related deaths and 6,000 cancer-related deaths in the year 2010. Of those deaths, 78 percent came in low-to-middle-income countries, not high-income nations. The researchers divided the results into nine different global regions. The most diabetes-related deaths came in the Latin America/Caribbean region, where a reported 38,000 people died as a result of drinking sugar-sweetened beverages. The greatest number of cardiovascular deaths (11,000) originated in the East/Central Eurasia. "Among the world's 15 most populous countries, Mexico - one of the countries with the highest per-capita consumption of sugary beverages in the world - had the highest death rate due to these beverages, with 318 deaths per million adults linked to sugar-sweetened beverage intake," the American Heart Association explained

Free statins in aisle 6: US supermarket chain giving away atorvastatin

In an attempt to gain a competitive edge over other retail outlets, Wegmans, a US supermarket chain with stores in the mid-Atlantic region, is offering free atorvastatin to its customers. The generic medication is available only to those with a prescription, but the hope is that the grocery store gains new customers by offering to fill these prescriptions at their pharmacies for no cost. The company intends to keep atorvastatin free until the end of 2013, according to a report in the Philadelphia Inquirer, after initially planning to end the promotion at the end of April. The company has not said how many new customers it has gained as a result of the promotion. Although supermarket loss leaders, the products sold at very low prices to draw customers into the store, typically include items such as soda, chips, or paper towels, it is not unheard of for US supermarkets and pharmacies to use generic medications as loss leaders. ShopRite gives seven diabetes drugs away for free as well as several antibiotics, notes the Inquirer. In addition, Meijer, a Midwestern store that sells everything from groceries to clothes to electronics, also gives atorvastatin away with a prescription. Lipitor, the branded version of atorvastatin made by Pfizer, was once a blockbuster medication for the company. In 2011, according to IMS Health, it had revenue of $8.2 billion. The patent expired in late 2011

Popular antibiotic gets cardiac warning

An antibiotic prescribed for a wide variety of infections may pose heart risks, the US Food and Drug Administration has warned. Azithromycin, sold as Zithromax or the "Z-Pak," may cause abnormal changes in the heart's electrical activity, the FDA said. Those changes may lead to a potentially deadly irregular heart rhythm, the agency added. Patients at risk include those with low blood levels of magnesium or potassium and heart rates that are slower than normal, the FDA said. People who take certain drugs for abnormal heart rhythms are at risk as well. Pfizer, which makes Zithromax, updated the drug's label about the rare heart rhythm abnormality in some patients. "It is important to note that other macrolide antibiotics are similarly labeled," the pharmaceutical company said. "It is also important to note that the majority of patients treated with Zithromax (azithromycin) are not affected by this label update." Zithromax is used to treat infections in the ear, lungs, reproductive organs, sinuses, skin and throat. Zithromax can be taken as a tablet or liquid. It may cause side effects, such as abdominal pain, diarrhea, nausea and vomiting

Chippies told to hold the salt in drive to beat heart disease (UK)

UK Government Ministers want to reduce the amount of salt in popular dishes, such as chips and sandwiches, to help prevent thousands of early deaths each year from heart disease and stroke. Food manufacturers and caterers will be set targets to help cut by a quarter the amount of salt consumed every day. Research suggests that more than half of shoppers "rarely or never" consider the amount of salt in food, despite 86 per cent knowing that too much is unhealthy. The Department of Health is aiming to help consumers reduce their salt intake from an average of 8.1g a day to 6g. Catering and takeaway companies will be set "maximum targets" for the salt content of their most popular dishes. Companies will also be urged to promote low-salt options

Lifesaving heart procedure expanded (Canada)

Since its inception in 2009, Sunnybrook's Schulich Heart Centre's TAVI program has provided access to a lifesaving heart procedure for 150 elderly or frail patients not well enough to undergo traditional aortic valve replacement surgery. Now, the centre will not only increase the number of TAVIs performed, but also share its expertise with other Canadian centres to ensure that patients across the country have access to the less invasive procedure. Transcatheter Aortic Valve Implantation, or TAVI, addresses the narrowing of the aortic valve, or "stenosis", a fairly common condition in today's aging population. If left untreated, stenosis can cause the heart muscle to thicken as it works harder to pump blood through the body, potentially leading to heart failure. The procedure takes between two and three hours, about half as long as conventional open-heart surgery for these complex patients, and may be carried out under general or local anaesthesia, with or without sedation. Benefits to patients include reduced pain and less need for postoperative pain medication, smaller scars, a shorter stay in the hospital and a faster recovery. Under the leadership of Dr. Sam Radhakrishnan, Director of the Cardiac Cath Labs and Physician-Lead of Sunnybrook's TAVI program and Dr. Stephen Fremes, surgical lead for the TAVI program, the hospital is guidingtraining for other Canadian hospitals to initiate their own TAVI programs

Atherosclerosis evident in four ancient populations, including hunter-gatherers

CT scans of mummies from four geographical regions across a period of 4000 years suggest that atherosclerosis was more common in ancient populations than previously believed. Studying individuals from ancient Egypt, ancient Peru, ancestral Puebloans of southwestern America, and hunter-gatherers from the Aleutian Islands, researchers were able to identify atherosclerosis in more than one-third of the mummified specimens, raising the possibility that humans have a natural predisposition to the disease. "Our findings greatly increase the number of ancient people known to have atherosclerosis and show for the first time that the disease was common in several ancient cultures with varying lifestyles, diets, and genetics, across a wide geographical distance and over a very long span of human history," according to the researchers. "These findings suggest that our understanding of the causative factors of atherosclerosis is incomplete and that atherosclerosis could be inherent to the process of human aging." The study is published March 10, 2013 in the Lancet to coincide with a presentation here at the American College of Cardiology 2013 Scientific Sessions

A new drug reduces heart damage

A single dose of an investigational anti-inflammatory drug called inclacumab considerably reduces damage to heart muscle during angioplasty (the opening of a blocked artery), according to a recent international clinical trial spearheaded by Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute, affiliated with the University of Montreal. Presented in San Francisco at the prestigious American cardiology conference, these findings show great promise. "Inclacumab could indeed become an integral part of the therapeutic arsenal of modern cardiology if we can reproduce these results in subsequent studies. We could use the drug for a broader patient population, or for all patients who present with a heart attack, but this will require further study," explained Dr. Tardif, lead investigator of the study and also professor of Medicine at Université de Montréal

Secondhand smoke riskier than cholesterol

The risk of clogged arteries is greater from secondhand smoke than from several well-known heart disease risk factors, including high cholesterol, researchers found. The overall prevalence of coronary artery plaque in those exposed to secondhand smoke was 24%, which rose to 26% in those with the highest exposure compared with 19% for the general public, Harvey S. Hecht, MD, of Mount Sinai Medical Center in New York City, and colleagues reported online in JACC: Cardiovascular Imaging. Those with the highest amount of exposure to passive smoke were 90% more likely to have coronary plaque compared with the general public. Even after adjusting for other cardiovascular risk factors, the odds associated with developing coronary disease from secondhand smoke were greater than from other well-established danger signs

Stress and artery health studied

"Stress really does increase the risk of heart attacks and strokes," reported the Daily Mail (UK). It said research has found that people who become stressed are more likely to suffer from hardened arteries. This study measured volunteers' levels of cortisol, a stress hormone, while they carried out tests aimed at raising their stress levels. It found that people who had increased cortisol levels were more likely to have high calcium deposits in the arteries, a marker of coronary heart disease. Although high calcium deposits may indicate heart disease, this study did not directly investigate if stress increases the risk of a heart attack or stroke. A single measure of stress taken at the same time as a measure of calcium build-up in the arteries cannot show whether a person’s lifetime stress habits have caused the build-up. Although further research is needed, minimising stress is known to be associated with improved mental and physical wellbeing. This research was carried out by Dr Mark Hamer and colleagues from University College London and Wellington Hospital. The study was funded by the British Heart Foundation and the Medical Research Council. The paper was published in the peer-reviewed European Heart Journal